La barrière capillaire enzymatique pour la DOPA au niveau de quelques noyaux du tronc cérébral du rat |
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| Authors: | J. Constantinidis G. Bartholini F. Geissbühler R. Tissot |
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| Affiliation: | (1) 1225 Genève, et Département de recherches scientifiques, Clinique universitaire de Psychiatrie, F. Hoffman-La Roche Cie., S.A., Basel, Suisse |
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| Abstract: | Summary An enzymatic barrier for Dopa exists at the level of the cerebral capillaries which changes Dopa into Dopamine by means of endothelial decarboxylase. It is abolished by a decarboxylase inhibitor. Its intensity is weaker in structures containing Dopamine (Striatum, Locus Niger). Neurones of the Raphé containing serotonin can be charged with catecholamines. There are close contacts between neurones and capillaries. |
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