The effect of a phorbol ester upon the cholinergic regulation of potassium permeability in the rat submandibular gland |
| |
Authors: | J. D. Pediani S. M. Wilson |
| |
Affiliation: | (1) The Institute of Physiology, University of Glasgow, G12 8QQ Glasgow, (Scotland, UK) |
| |
Abstract: | Acetylcholine releases calcium from cytoplasmic stores and permits an influx of calcium in salivary acinar cells. The resultant rise in [Ca2+]i causes an increase in potassium permeability which is an important part of the secretory response. We have investigated the effects of 12-0-tetradecanoyl phorbol-13-acetate, a potent activator of protein kinase C, upon this regulation of potassium permeability in superfused pieces of rat submandibular salivary gland. This compound inhibited the initial [Ca2+]o-independent component of the response of acetylcholine but had no effect upon the subsequent [Ca2+]o-dependent phase. This compound does not, therefore, appear to inhibit receptor-regulated calcium influx. |
| |
Keywords: | Salivary gland phorbol ester potassium permeability 86Rb+-efflux stimulus-response coupling protein kinase C |
本文献已被 SpringerLink 等数据库收录! |