Response of murine spermatocytes to the metaphase-arresting effect of several mitotic arrestants |
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| Authors: | J C Liang T C Hsu M Gay |
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| Institution: | (1) Department of Genetics, The University of Texas M.D. Anderson Hospital, 77030 Houston, Texas, USA;(2) Tumor Institute at Houston, 77030 Houston, Texas, USA |
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| Abstract: | Summary Three mitotic arrestants, colchicine, Colcemid and vinblastine, were evaluated for their effects on producing meiotic arrest in the laboratory mouse. Colchicine is the most effective and its effect is both dose- and time-dependent. Treatment of mice with 40 mg/kg of colchicine for 3 h resulted in drastic improvement of the yield and quality of M-II figures. This treatment did not appear to increase the aneuploidy frequency in M-II's.Supported in part by research grant R-808582 from the US Environmental Protection Agency and research grant RR5511-21 from the National Institute of Health. |
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| Keywords: | Mitotic arrestants spermatocyte chromosomes meiotic metaphase accumulation |
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