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ACTH-induced hyperalgesia in rats. |
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| Authors: | A Bertolini R Poggioli W Ferrari |
| Abstract: | The injection of ACTH 1--24 into the cerebral ventricles in rats markedly reduces the reaction time in the hot-plate test and the nociception threshold in the tail-stimulation test. Morphine antagonizes and naloxone potentiates this hyperalgesic effect of ACTH. It is proposed that ACTH peptides play a physiological role in nociception. |
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