Increased ALA dehydratase activity and spleen weight in lead-intoxicated rats. A consequence of increased blood cell destruction |
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Authors: | J Maes G B Gerber |
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Institution: | (1) Department of Radiobiology, Euratom and Centre d'Etude de l'Energie Nucléaire, B-2400 Mol, (Belgium) |
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Abstract: | Summary Lead was given in the diet (1%) to rats from birth and at different times the animals were studied for delta amino levulinic acid dehydratase (ALAD) activity, spleen weight,59Fe incorporation in erythrocytes and51Cr-labeled erythrocytes survival. The increased ALAD and spleen weight found after lead treatment is explained as a consequence of a shortened survival, which results in a younger age of circulating erythrocytes with higher ALAD activity.Supported by Contract No. 140-76-12 ENV. B. of the E. C. Environmental Research Program. |
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