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Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs |
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| Authors: | C J March B Mosley A Larsen D P Cerretti G Braedt V Price S Gillis C S Henney S R Kronheim K Grabstein |
| Abstract: | Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-1 alpha and IL-1 beta), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity. |
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