The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat |
| |
| Authors: | L Manzo R Passoni A D Segre F Bertè A Crema |
| |
| Institution: | (1) Istituto di Farmacologia Medica, Università di Pavia, Piazza Botta 10, I-27100 Pavia, (Italy);(2) Present address: Laboratori Causyth, Via Serio 6, I-20139 Milano, Italy |
| |
| Abstract: | Summary Oxine-5-sulphonic acid inhibits the metabolism of aminopyrine in the rat liver in vitro. The characteristics of this inhibition vary according to whether the oxidativeN-demethylation of the substrate is determined by the formation of the metabolite 4-aminoantipyrine or by the production of formaldehyde. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
