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Recent developments of the stoichiometric displacement model for separation processes
Authors:Xindu Geng  Fred E Regnier  Yan Wang
Institution:(1) Institute of Modern Separation Science, Northwest University, the Key Lab of Modern Separation Science of Shaanxi Province, 710069 Xi’an, China;(2) Department of Chemistry, Purdue University, 4 7907 West Lafayette, IN, USA
Abstract:Substantial attention has been paid to the stoichiometric displacement models for solute retention (SDM-R) in liquid chromatography and adsorption (SDM-A) at surfaces since they were developed. The SDM has a strongly theoretical basis and has evolved to the point that it is widely applied in chemistry, biochemistry, molecular biology and biotechnology. This review introduces the history, recent developments, and new concepts relating to the SDM, including theory, mathematical expressions, and applications across a broad range of fields.
Keywords:liquid chromatography  liquid-solid system  stoichiometric displacement retention model  absorption mechanism  protein folding
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