Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. |
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| Authors: | E J Neufeld D G Skalnik P M Lievens S H Orkin |
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| Institution: | Division of Hematology/Oncology, Children's Hospital, Boston, Massachusetts. |
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| Abstract: | Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified from HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda gt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats". As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development. |
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