Heat shock protein gene expression during Xenopus development |
| |
Authors: | J J Heikkila N Ohan Y Tam A Ali |
| |
Institution: | (1) Department of Biology, University of Waterloo, Ontario N2L 3G1 (Canada), Fax +1 519 746 0614, e-mail: heikkila@sciborg.uwaterloo.ca, CA |
| |
Abstract: | Stress-induced heat shock protein gene expression is developmentally regulated during early embryogen esis of the frog, Xenopus laevis. For example, a number of heat shock protein genes, such as hsp70,
hsp90, and ubiquitin are not heat-inducible until after the midblastula stage of embryogenesis. Furthermore, the family of small heat shock protein
genes, hsp30, are differentially expressed after the midblastula stage as well as being regulated at the level of mRNA stability. Many
of these stress proteins are also synthesized constitutively during oogenesis and embryogenesis during which they may act
as molecular chaperones as well as being involved in sequestering proteins in an inactive state until required by the developing
embryo. Furthermore the induction of these stress protein genes has been correlated with enhanced thermoresistance. During
stressful conditions heat shock proteins probably prevent aggregation or misfolding of damaged protei
ns within the embryo. |
| |
Keywords: | ,Xenopus, heat shock, stress, heat shock protein, development, gene regulation, |
本文献已被 SpringerLink 等数据库收录! |
|