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| 基于电化学的血清蛋白-铅络合物的络合及其解离 | |
| 引用本文： | 梁莹,潘锐,魏学锋,周鸣,董铁有.基于电化学的血清蛋白-铅络合物的络合及其解离[J].河南科技大学学报(自然科学版),2011,32(1):93-96,122. |
| 作者姓名： | 梁莹 潘锐 魏学锋 周鸣 董铁有 |
| 作者单位： | 1. 河南科技大学化工与制药学院,河南,洛阳,471003 2. 河南科技大学第三附属医院,河南,洛阳,471003 3. 河南科技大学环境工程研究所,河南,洛阳,471003 |
| 基金项目： | 河南省医学科技攻关基金项目(200703081); 河南省教育厅自然科学基金项目(2009A150008); 河南科技大学科学研究基金项目(2007ZY037) |
| 摘 要： | 为解决现有重金属中毒治疗中存在的问题,用铅与牛血清蛋白生成的络合物作为中毒模拟血液,对其进行透析,判断铅与牛血清蛋白的络合性能.根据蛋白质分子中多肤链拥有游离氨基和游离羧基以及氨基酸的两性电解质特性,提出采用基于电化学原理的血清蛋白一铅络合物的解离问题,并就解离能的提供方式及其机理进行研究.建立了"外加直流电场一铅络合... |
| 关 键 词： | 铅污染 络合物 模拟血液 透析 电解 |
Complex Formation and Dissociation of Pb-serum Albumin Complex Based on Electrodynamics |
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| LIANG Ying,PAN Rui,WEI Xue-Feng,ZHOU Ming,DONG Tie-You.Complex Formation and Dissociation of Pb-serum Albumin Complex Based on Electrodynamics[J].Journal of Henan University of Science & Technology:Natural Science,2011,32(1):93-96,122. | |
| Authors: | LIANG Ying PAN Rui WEI Xue-Feng ZHOU Ming DONG Tie-You |
| Institution: | LIANG Yinga,PAN Ruib,WEI Xue-Fenga,ZHOU Minga,DONG Tie-Youc (a.Chemical Engineering & Pharmaceutics School,b.The Third Affiliated Hospital,c.Enviroment Engineering Research Insitute,Henan University of Science & Technology,Luoyang 471003,China) |
| Abstract: | In order to solve the problems concerning with the treatment of heavy metal poisoning,the complex generating by lead and bovine serum protein was used as simulation of poisoning blood.The simulation of poisoning blood was dialysed to determine the complexation properties of lead and bovine serum protein.Because polypeptide chains in the protein molecules had free amino and free carboxyl,and amino acids had gender electrolyte characteristics,the dissociation of the complex generating by lead and bovine serum... |
| Keywords: | Lead polution Complex Simulation of poisoning blood Dialysis Electrolysis |
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