The effect of urethane and pentobarbital anaesthesia and hepatic portal vein catheterization on liver blood flow in the rat |
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| Authors: | C. R. Hiley M. S. Yates D. J. Back |
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| Affiliation: | (1) Department of Pharmacology and Therapeutics, University of Liverpool, P.O. Box 147, L69 3BX Liverpool, (England) |
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| Abstract: | Summary The effect of urethane and pentobarbital anaesthesia and hepatic portal vein catheterization on liver blood flow was investigated in the rat. Liver blood flow with pentobarbital anaesthesia was 40% greater than with urethane. Hepatic portal vein catheterization had no effect under pentobarbital anaesthesia whereas it produced an 18% fall in liver blood flow with urethane.Acknowledgments. This work was supported by grants from ICI Pharmaceuticals and Mersey Regional Health Authority (Research Scheme No. 338). We wish to thank Mr P.J. Roberts for much skilled assistance and Evans Medical Ltd for the kind gift of drugs. |
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