| 3-溴-5-硝基苯基苄基醚的克级制备方法研究 |
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| 引用本文： | 杨帆,刘许歌,王应飞,沈悦海.3-溴-5-硝基苯基苄基醚的克级制备方法研究[J].云南民族大学学报(自然科学版),2013,22(5):327-329. |
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| 作者姓名： | 杨帆 刘许歌 王应飞 沈悦海 |
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| 作者单位： | 昆明理工大学生命科学与技术学院,云南昆明,650500 |
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| 基金项目： | 国家自然科学基金，云南省自然科学基金 |
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| 摘 要： | 报道了3-溴-5-硝基苯基苄基醚的制备方法 .苄醇对3,5-二硝基溴苯的芳香亲核取代反应极易受后续副反应的影响,对反应中碱、溶剂、浓度、温度、反应时间和投料量等因素进行了系统的研究,发现在DMF中50℃下与苄醇和叔丁醇钾反应10 min可以高产率得到克级目标产物.反应体系的颜色变化可作为判断反应终点的指标.
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| 关 键 词： | 3-溴-5-硝基苯基苄基醚 芳香亲核取代 克级制备 |
Multi-gram scale synthesis of 3-bromo-5-nitrophenyl benzyl ether |
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| YANG Fan
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LIU Xu-ge
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WANG Ying-fei
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SHEN Yue-hai.Multi-gram scale synthesis of 3-bromo-5-nitrophenyl benzyl ether[J].Journal of Yunnan Nationalities University:Natural Sciences Edition,2013,22(5):327-329. |
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| Authors: | YANG Fan LIU Xu-ge WANG Ying-fei SHEN Yue-hai |
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| Institution: | YANG Fan;LIU Xu-ge;WANG Ying-fei;SHEN Yue-hai;Faculty of Life Science and Technology,Kunming University of Science and Technology; |
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| Abstract: | A practical multi-gram scale synthesis of 3-bromo-5-nitrophenyl benzyl ether was developed.The aromatic nucleophilic substitution of benzyl alcohol to 1-bromo-3,5-dinitrobenzene was found highly sensitive to the following side reactions.After a detailed evaluation of the reaction parameters,including the base,solvent,concentration,temperature,time,and reaction scale,the research found the target product could be obtained reliably at the multi-gram scale by stirring it with benzyl alcohol and potassium tert-butoxide in DMF at 50℃ for several minutes.The color change of the reaction system was found an accurate indicator of the end of this reaction. |
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| Keywords: | 3-Bromo-5-nitrophenyl benzyl ether aromatic nucleophilic substitution multi-gram scale synthesis |
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