The dynamics of CD4+ T-cell depletion in HIV disease |
| |
Authors: | McCune J M |
| |
Institution: | Gladstone Institute of Virology and Immunology, Departments of Medicine and Microbiology and Immunology, University of California at San Francisco, 94141-9100, USA. mmccune@gladstone.ucsf.edu |
| |
Abstract: | The size and composition of the CD4+ T-cell population is regulated by balanced proliferation of progenitor cells and death of mature progeny. After infection with the human immunodeficiency virus, this homeostasis is often disturbed and CD4+ T cells are instead depleted. Such depletion cannot result simply from accelerated destruction of mature CD4+ T cells - sources of T-cell production must also fail. Ironically, this failure may be precipitated by physiological mechanisms designed to maintain homeostasis in the face of accelerated T-cell loss. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|