Cellular control of the tick-borne virus antigen production in persistently infected cell culture |
| |
Authors: | Yu. S. Boriskin N. N. Bogomolova |
| |
Affiliation: | (1) Moscow Institute for Viral Preparations, 1st Dubrovskaya Street, 109088 15 Moskwa, (USSR) |
| |
Abstract: | Summary The influence of inhibition or stimulation of cellular DNA synthesis on tick-borne virus antigen production in persistently infected cell culture was studied. Either mitomycin C or cytosine-arabinoside caused cessation of antigen-containing cell number increase. Stimulation of cellular DNA synthesis by growth medium change increased the level of antigen-containing cells. When HEp-2-Sof culture was synchronized, a correlation was observed between the entrance of cells into DNA synthesis phase and the increase of proportion of antigen-containing cells. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |