| 手性伯胺催化Biginelli反应合成手性嘧啶酮化合物的影响因素研究 |
| |
| 引用本文： | 周伟,赵金刚,林晶,徐燕霞,刘珺,赵淑娟,谢恬. 手性伯胺催化Biginelli反应合成手性嘧啶酮化合物的影响因素研究[J]. 杭州师范大学学报(自然科学版), 2012, 0(4): 352-358 |
| |
| 作者姓名： | 周伟 赵金刚 林晶 徐燕霞 刘珺 赵淑娟 谢恬 |
| |
| 作者单位： | 杭州师范大学生物医药与健康研究中心 |
| |
| 基金项目： | 杭州市重大科技专门项目(20092113A03) |
| |
| 摘 要： | 手性嘧啶酮类化合物具有重要的药理活性应用.采用手性伯胺与金属盐的复合催化体系催化Bigi-nelli反应,可以得到高立体选择性的手性嘧啶酮化合物.通过对各种反应条件的考察,结果表明,在NbCl5与QN-NH2的协同催化作用下得到较为理想的e.e.值(69%)和产率(74%).
|
| 关 键 词： | 手性嘧啶酮化合物 Biginelli反应 金属 手性伯胺催化剂 |
The Influencing Factors on the Synthesis of Chiral Pyrimidine Sulfo-Benzophenone Compounds Catalyzed by Chiral Primary Amine-Based Organocatalyst in Biginelli Reaction |
| |
| ZHOU Wei,ZHAO Jin-gang,LIN Jing,XU Yan-xia,LIU Jun,ZHAO Shu-juan,Xie Tian. The Influencing Factors on the Synthesis of Chiral Pyrimidine Sulfo-Benzophenone Compounds Catalyzed by Chiral Primary Amine-Based Organocatalyst in Biginelli Reaction[J]. , 2012, 0(4): 352-358 |
| |
| Authors: | ZHOU Wei ZHAO Jin-gang LIN Jing XU Yan-xia LIU Jun ZHAO Shu-juan Xie Tian |
| |
| Affiliation: | (Center for Biomedicine and Health,Hangzhou Normal University,Hangzhou 311121,China) |
| |
| Abstract: | Chiral pyrimidine ketone compounds have important pharmacological activities and broad applications in many fields.Chiral pyrimidine sulfo-benzophenone compounds with high enantioselectivity were obtained by the Biginelli reaction,which was catalyzed by chiral primary amine and metal salt.The results show that e.e.can be up to 69% and yield can be up to 76% under the influence of synergistic catalysis of NbCl5 and QN-NH2. |
| |
| Keywords: | chiral pyrimidine sulfo-benzophenone compounds Biginelli reaction metal chiral primary amine-based organocatalysts |
| 本文献已被 CNKI 等数据库收录！ |
