Is glutamic acid the pyramidal tract neurotransmitter? |
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| Authors: | T. W. Stone |
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| Affiliation: | (1) Department of Physiology, University of Aberdeen, Marischal College, AB9 1AS Aberdeen, Scotland |
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| Abstract: | Summary Applied by microiontophoresis, 1-hydroxy-3-amino-pyrrolidone-2 (HA-966) antagonized excitation by glutamic acid but not by acetylcholine of neurones in the rat cuneate nucleus. HA-966 blocked the short latency excitation of cuneate neurones following stimulation of the pyramidal tract on 28 of 40 cells (70%). Thus, glutamate or a related amino-acid may be the neurotransmitter released by pyramidal tract neurones.Acknowledgment. I wish to thank Dr.J. C. Watkins for the gift of a sample of HA-966. |
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