| Molecular Cloning of a Novel Bovine Homologue of the Drosophila Tumor Suppressor Gene,Lats |
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| 作者姓名： | 卢刚 Hao Xinming Wu Xiaohui Xu Tian Chen Weili |
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| 作者单位： | [1]InstituteofDevelopmentalBiology,FudanUniversity,Shanghai200433,P.R.China [2]Authorforcorrespondence－E－mail：Wl_Chen@hotmail.com,FudanUniversity,Shanghai200433,P.R.China |
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| 摘 要： | Pervious studies demonstrate that lats,also known as warts,is a tumor suppressor gene in Drosophila^1,2],Mutations of lats lead to an increase in cell number and organ size in Drosophila,indicating lats may be involved in organ size control.Furthermore,the high conservation of sequence and tumor suppression functioin of lats between Drosophila and human suggests that it may be also involved in organ size control of higher animals^3],So here we isolated the bovine homologue of Drosophila lats.Sequence analysis indicates the bovine LATS1 to be very similar to other lats proteins.
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| 关 键 词： | 牛同系物 肿块抑制基因 Lats |
Molecular Cloning of a Novel Bovine Homologue of the Drosophila Tumor Suppressor Gene, Lats |
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| Hao Xinming,Wu Xiaohui,Xu Tian,Chen Weili.Molecular Cloning of a Novel Bovine Homologue of the Drosophila Tumor Suppressor Gene,Lats[J].High Technology Letters,2002,8(2):1-4. |
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| Authors: | Hao Xinming Wu Xiaohui Xu Tian Chen Weili |
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| Abstract: | Pervious studies demonstrate that lats, also known as warts, is a tumor suppressor gene in Drosophila1,2]. Mutations of lats lead to an increase in cell number and organ size in Drosophila, indicating lats may be involved in organ size control. Furthermore, the high conservation of sequence and tumor suppression function of lats between Drosophila and human suggests that it may be also involved in organ size control of higher animals3]. So here we isolated the bovine homologue of Drosophila lats. Sequence analysis indicates the bovine LATS1 to be very similar to other lats proteins. |
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| Keywords: | bovine tumor suppressor lats |
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