Temperature-dependence of stress-induced hepatic autophagy |
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| Authors: | M. Salas B. Tuchweber P. Kourounakis H. Selye |
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| Affiliation: | (1) Institut de Médecine et de Chirurgie Expérimentales, Université de Montréal, H3C 3J7 Montréal, Québec, Canada;(2) Present address: Institut du Cancer de Montréal, Centre hospitalier Notre-Dame, H2L 4M1 Montréal, Québec, Canada;(3) Present address: Département de nutrition, Faculté de médecine, Université de Montréal, H3C 3J7 Montréal, Québec, Canada;(4) Present address: Laboratory of Pharmaceutical Chemistry Department of Pharmacy, University of Thessaloniki, Thessaloniki, Greece |
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| Abstract: | Summary In rats, restraint for 48 h elicits hepatic glycogen depletion, autophagy and other ultrastructural changes (e.g. mitochondrial enlargement and rough endoplasmic reticulum disorganization) associated with marked hypothermia. By restoring the body temperature of these animals, all the hepatocytic alterations are abolished.Supported in part by the Medical Research Council of Canada (Block Term Grant MT-1829) and the Conseil de la recherche en santé du Québec. A preliminary report of this work was presented at the 19th Annual Meeting of the Canadian Federation of Biological Societies, Halifax, 15–18 June 1976.Recipient of a studentship from the Conseil de la recherche en santé du Québec.The authors thank Mr M. Audet, Mrs A. Perea and Miss F. Dionne, for their excellent technical assistance. |
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