Asymmetric reduction of aromatic ketones catalyzed by using (αs, 4s)-2-dichloromethyl-4, 5-dihydro-α-(4-nitrophenyl)-4-oxazolemethanol-borane complex |
| |
Authors: | Shi Yu Hu Quan-yuan Yang Shao-rong Hu Xian-ming |
| |
Institution: | (1) College of Pharmacy, Wuhan University, 430072 Wuhan, Hubei, China |
| |
Abstract: | Chiral oxazoborolidine borane complex was prepared from (αs, 4s)-2-dichloromethyl-4, 5-dihydro-α-(4-nitrophenyl)-4-oxazolemethanol
with Borane in THF. The borane modified by chiral oxazoborolidine enantioselectively reduced aromatic ketones to second-alcohol
with about 95% yield and medium optical yields. In the end of article, results are discussed and reduction mechanism is shown
which proves the resulting major isomers fit very well.
Foundation item: Sopported by DSM Andeno of Holland
Biography: Shi Yu (1975-), Master candidate, research direction: asymmetric, synthesis. |
| |
Keywords: | asymmetric reduction prochiral ketones chiral oxazoborolidine borane chloramphenicol oxazoline |
本文献已被 SpringerLink 等数据库收录! |
|