| 溃疡性结肠炎大鼠模型及其结肠电异常 |
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| 引用本文： | 张永斌,邹移海,连至诚,陈苇菁.溃疡性结肠炎大鼠模型及其结肠电异常[J].实验动物科学,2002,19(2):5-7. |
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| 作者姓名： | 张永斌 邹移海 连至诚 陈苇菁 |
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| 作者单位： | 1. 广州中医药大学实验动物中心,广州,510407
2. 广州中医药大学脾胃研究所,广州,510407 |
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| 基金项目： | 广东省自然科学基金资助项目 (No.96 0 5 45 ) |
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| 摘 要： | 目的 制作大鼠溃疡性结肠炎 (UC)模型 ,研究结肠电异常。方法 以二硝基氯苯法制作溃疡性结肠炎模型 ,埋藏电极记录结肠电。结果 造模大鼠结肠形成典型的溃疡 ,并发现其结肠电活动明显异常 ,具体表现为基本电节律 (BER)减慢及收缩性复合肌电 (CEC)的幅值显著降低 ,负载峰电的BER和CEC百分数明显减少
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| 关 键 词： | 溃疡性结肠炎 动物模型 |
| 文章编号： | 1006-6179(2002)02-0005-03 |
| 收稿时间： | 2002-06-25 |
| 修稿时间： | 2002年3月14日 |
Experimental Model of Ulcerative Colitis in Rat and Its Abnormality of Colonic Eletricity |
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| ZHANG Yong-bin,ZOU Yi-hai,LIAN Zhi-cheng,CHEN Wei-qing.Experimental Model of Ulcerative Colitis in Rat and Its Abnormality of Colonic Eletricity[J].Shiyan Dongwu Kexue,2002,19(2):5-7. |
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| Authors: | ZHANG Yong-bin ZOU Yi-hai LIAN Zhi-cheng CHEN Wei-qing |
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| Institution: | ZHANG Yong-bin+1,ZOU Yi-hai+1,LIAN Zhi-cheng+2,CHEN Wei-qing+2 |
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| Abstract: | objective To establish a rat ulcerative colitis(UC) model and observe the abnormality of its electrical activity of colon.Methods The rat-models of ulcerative colitis were induced by 2,4-dinitrochlorobenzene(DNCB),an electrode was buried in rats' colon and their colonic electricity was recorded.Conclusion It was found that colon of rat-models developed typical ulceration and colonic electricity was abnormal,the basic electric rhythm(BER) of colon was slowed;extent of contractile electrical complex(CEC) was decreased and the percentage of BER and CEC loaded with peak electricity were markedly lowered. |
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| Keywords: | Ulcerative colitis Animal model Elcetrical activity of colon |
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