皮质发育障碍模型鼠与正常鼠致痫的性别特点

目的 探讨X射线诱导的皮质发育障碍(DCDs)模型鼠与正常对照鼠致痫的性别特点.方法 将8只SD孕鼠完全随机分为正常对照组和实验组,实验组于X线直线加速器照射制作皮质发育障碍模型,正常对照组不做任何处理,仔鼠成年后按性别分成4组.分别给正常对照组雄雌性及实验组雄雌性仔鼠腹腔注射氯化锂-匹洛卡品,观察产生癫痫的潜伏期、注射总剂量、癫痫发生率.结果 腹腔注射氯化锂-匹洛卡品后DCDs雄鼠较雌鼠发生癫痫潜伏期明显缩短(P＜0.01),注射总剂量显著减少(P＜0.01),癫痫发生率高(P＜0.05).正常组雄鼠较雌鼠发生癫痫潜伏期缩短(P＜0.05)、注射总剂量减少(P＜0.05),癫痫发生率未见明显差异.结论 DCDs及正常鼠中雄性鼠较雌性鼠易感性高,更适于造模.

Gender Characteristics of Seizures in Disorder of Cortical Developments and Normal Rats

Objective To discuss the gender characteristics of seizures in the rat model of disorder of cortical developments（DCDs） induced by X-ray irradiation treatment and in the normal rats. Methods Eight pregnant SD rats were randomly divided into experimental group and control group. In the experimental pregnant group ：the rat model of X-ray irradiation-induced DCDs were produced with linear accelerator. In the control group：No treatment. All P60 offspring were divided into four groups by gender;The four groups were injected with LiCl-pilocarpine intra-peritoneally respectively and detected the latency to seizure onset, total drug doses, occurrence of epilepsy. Results After injecting LiCl-piloearpine intra-peritoneally, the DCDs male group had obvious shorter latency to seizure （ P 〈 0.01 ） , less doses （ P 〈 0. 01 ） , higher occurrence of epilepsy （ P 〈 0. 05 ） , compared with the DCDs female group ; And the normal male group also had shorter latency to seizure （ P 〈 0. 05 ） , less doses（ P 〈 0.05 ）, While occurrence of epilepsy had not seen the obvious difference, compared with normal female group, Conclusion DCDs and normal male rats had higher susceptibility than those female SD rats , and been more suitable for building model