Organoselenides as potential immunostimulants and inducers of interferon gamma and other cytokines in human peripheral blood leukocytes |
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Authors: | A. D. Inglot J. Zielińska-Jenczylik E. Piasecki L. Syper J. Młochowski |
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Affiliation: | (1) Laboratory of Virology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Czerska 12, 53-114 Wroc aw, (Poland);(2) Institute of Organic and Physical Chemistry, Technical University, Wybrze e Wyspia skiego 27, 50-370 Wroc aw, (Poland) |
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Abstract: | Summary A number of organoselenium compounds have been described as anti-inflammatory, antioxidant, glutathione peroxidase-like agents and inhibitors of prostaglandin synthesis. Here we report that bis [2-(N-phenyl-carboxamido)]phenyl diselenide, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen) and related compounds are inducers of interferon gamma (IFN- ) and tumor necrosis factor (TNF) in human peripheral blood leukocytes. The IFN and TNF response was rapid, occurring within 20 h, and high-up to 1000 and 2000 units ml–1-and was clearly related to the dosage and the structure of the compounds. The action of the compounds and phytohemagglutinin was synergistic. The IFN gamma and TNF production was reduced after removing adherent cells. Although the mode of action of the compounds is not known, they appear to interact directly or indirectly with both adherent and non-adherent leukocytes, and stimulate the synthesis of a set of different cytokines including factors controlling the cell proliferation. Therefore, organoselenides may be regarded as the biological response modifiers. |
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Keywords: | Organoselenium compounds Ebselen interferon gamma tumor necrosis factor human peripheral blood leukocytes interferon inducers phytohemagglutinin antiviral agents |
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