Immunocytochemical demonstration of calmodulin in cells secreting by exocytosis |
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| Authors: | C Egsmose MD E Bock K Møllgård N A Thorn |
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| Institution: | (1) The Protein Laboratory, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, (Denmark);(2) The Panum Institute (Institutes of Medical Anatomy A and Medical Physiology C), Blegdamsvej 3, DK-2200 Copenhagen N, (Denmark) |
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| Abstract: | Summary Calmodulin is a regulator of several calcium-dependent cellular processes. It has been suggested that it plays a role in the mechanism of secretion. Employing an indirect immunoperoxidase technique at the light microscope level, this study demonstrates the presence of calmodulin in several exocytotic cells (mast cells, thyroid follicular cells, neurohypophyseal neurosecretory terminals, pancreatic -cells and pancreatic acinus cells) in rat and man. The positive staining reaction for calmodulin was granular and at least in the case of rat mast cells it appeared to be associated with the granule membrane. |
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| Keywords: | Immunocytochemistry calmodulin secretory granules |
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