Action of glutamic acid and of some glutamate analogues on the molluscan central neurones |
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Authors: | F. Eusebi P. Palmieri M. Picardo |
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Affiliation: | (1) Istituto Fisiologia Umana, II Cattedra, University of Rome, Città universitaria, Roma, (Italy) |
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Abstract: | Summary The effects of L-glutamic acid and of some glutamate analogues have been studied on the central nervous system of the snailHeobania vermiculata, using conventional electrophysiological techniques. The glutamate H-response had the mean equilibrium value of-(57±4) mV and was associated with a Cl– conductance change. The D-response to glutamate application showed an involvement of sodium ions. Aspartate was agonist of glutamate action and displayed similar equilibrium value of the H-response, whereas quisqualate H-response was non-invertible.The authors wish to express their thanks to Prof. A. Curatolo for his continual interest and advice, and to Dr J. Stinnakre for the criticism of the text. |
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