Comparison of X-prolyl dipeptidyl-aminopeptidase activity in human cerebrospinal fluid with that in serum |
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| Authors: | T. Kato K. Iwase T. Nagatsu S. Sakakibara K. Fujita |
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| Affiliation: | (1) Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology, 227 Yokohama, (Japan);(2) Peptide Institute, Protein Research Foundation, 562 Minoh, Osaka, (Japan);(3) School of Medicine, Fujita-Gakuen University, 470-11 Toyoake, Aichi, (Japan) |
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| Abstract: | Summary X-Prolyl dipeptidyl-aminopeptidase activities in cerebrospinal fluid and serum from the same patients without neurological diseases, undergoing surgery under lumbar anesthesia, were assayed fluorometrically with a newly synthesized fluorogenic substrate, 7-glycylproline-4-methylcoumarinamide; the values were 129.1±19.5 nmoles/min/1 and 54.17±3.11  moles/min/1 (mean±SEM, n=23), respectively, and there was no correlation between both activities (r=0.0894). |
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