Stimulation of pyruvate carboxylation by gastric secretagogues |
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| Authors: | E. de Bohórquez J. Chacín |
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| Affiliation: | (1) Unidad de Investigaciones Biológicas, Facultad de Medicina, Universidad del Zulia, Apartado Postal 526, Maracaibo, (Venezuela) |
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| Abstract: | Summary Pyruvate carboxylation was stimulated by 2 gastric secretagogues, histamine and dibutyryl cyclic AMP, and by butyrate. Thiocyanate, an inhibitor of acid secretion, produced a slight decrease. Avidin significantly reduced acid secretion and this effect was overcome by biotin and oxalacetate. The results suggest that carboxylation of pyruvate is one of the reactions controlling oxidative metabolism and acid secretion in toad gastric mucosa.This investigation was supported by Consejo de Desarrollo Científico y Humanístico de la Universidad del Zulia, and by CONICIT Grant S1-0455. |
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