| 摘 要： | Glutamate and Ⅱ-aminobutyric acid (GABA) are important neurotransmitters in the retinal neuronal circuitry. Using the whole-cell patch clamp technique and a rapid solution changer, glutamate and GABA receptors in the retina have been extensively investigated. Results indicate that glutamate receptors on horizontal cells may be an AMPA preferring subtype, which predominantly consists of flop splice variants. GABAA and GABAC receptors coexist in bipolar cells, with the latter showing significant desensitization. Kinetics analysis has demonstrated that the activation, deactivation and desensitization of the GABAC receptor-mediated response of these cells are overall slower than those of the GABAA response. Endogenous modulator Zn2 + in the retina has been found to differentially modulate the kinetic characteristics of the GABAC and GABAA responses.
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