| 海人酸致沙鼠癫痫模型初探 |
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| 引用本文： | 李胜利,乔欣,王钜.海人酸致沙鼠癫痫模型初探[J].实验动物科学,2006,23(4):16-17. |
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| 作者姓名： | 李胜利 乔欣 王钜 |
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| 作者单位： | 首都医科大学实验动物科学部,北京,100069 |
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| 基金项目： | 北京市科委248重大科技项目 |
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| 摘 要： | 采用腹腔注射海人酸(KA)的方法制作沙鼠癫痫模型。结果显示,实验中所设的四个剂量组(5 mg/kg,10mg/kg,15 mg/kg,20 mg/kg)均能成功诱发癫痫发作,是良好的颞叶癫痫动物模型。随着KA剂量的增加,沙鼠癫痫发作的潜伏期、发作时间均明显缩短(P<0.01),但动物的死亡率增加(P<0.01)。提示制作沙鼠癫痫模型时腹腔注射KA的适宜剂量是5 mg/kg。
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| 关 键 词： | 沙鼠 癫痫 海人酸 |
| 文章编号： | 1006-6179(2006)04-0016-02 |
| 收稿时间： | 2006-12-25 |
| 修稿时间： | 2006年2月10日 |
The Primary Study on the Establishment of a Model of Epilepsy Induced by Kainic Acid in Gerbils |
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| LI Sheng-li,QIAO Xin,WANG Ju.The Primary Study on the Establishment of a Model of Epilepsy Induced by Kainic Acid in Gerbils[J].Shiyan Dongwu Kexue,2006,23(4):16-17. |
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| Authors: | LI Sheng-li QIAO Xin WANG Ju |
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| Abstract: | Objective Kainic acid was used in inducing epilepsy model in gerbils.The results showed that the model could be established by intraperitioneal injection of four doses of KA(5,10,15,20mg/kg), and it also showed the latent period and the time of seizure was significantly reduced (P<0.01) and the dead rate was increasing significantly(P<0.01).It indicates that the dose of 5mg/kg is perfect in establishing epilepsy model in gerbils. |
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| Keywords: | Gerbil Epilepsy Kainic acid |
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