A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures |
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| Authors: | D P Cardinali María I Vacas Mónica N Ritta |
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| Institution: | (1) Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Obligado 2490, 1428 Buenos Aires, (Argentina) |
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| Abstract: | Summary Physiological amounts of estradiol (1 nM) significantly increased serotonin, conversion to melatonin and 5-methoxytryptophol by rat pineal glands in organ culture whereas larger, pharmacological, doses (i.e. 1000 nM) impaired it significantly. The stimulatory but not the inhibitory effect of estradiol was blocked by the simultaneous addition of puromycin in the culture medium.This study was supported by grant No. 6638 from the Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), Argentina. |
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