Melatonin decreases the amplitude of the b-wave of the human electroretinogram |
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Authors: | W Emser R Dechoux M Weiland A Wirz-Justice |
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Institution: | (1) Department of Neurology and Sleep Research Centre for Psychobiology, University of Trier, Caritas-Krankenhaus, D-66763 Dillingen/Saar, (Germany);(2) Psychiatric University Clinic, CH-4025 Basel, (Switzerland) |
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Abstract: | In a double-blind placebo crossover study of 13 healthy volunteers, the pineal hormone melatonin (10 mg) was given at 4 pm, and the electroretinogram measured under conditions of dark and light adaptation. A significant diminution of b-wave amplitude was found under both photopic ( =5.4 V, p<0.05) and scotopic conditions ( =7.4 V, p<0.01). These data indicate that melatonin may transduce the dark signal at the level of the retina as well as the pineal. Acute administration of melatonin decreases sensitivity to light. |
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Keywords: | Melatonin human electroretinogram b-wave |
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