The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus |
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Authors: | N M Dixit A S Perelson |
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Institution: | (1) Department of Chemical Engineering, Indian Institute of Science, Bangalore, India, 560012;(2) Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA |
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Abstract: | Ribavirin, a broad spectrum antiviral agent, in conjunction with interferon forms the current standard of treatment for hepatitis
C virus (HCV) infection in humans. While ribavirin alone fails to induce a significant antiviral response, in combination
with interferon, ribavirin dramatically improves the long-term outcome of therapy. The predominant mechanism(s) of ribavirin
action against HCV, are yet to be established. In this review, we examine the current status of our understanding of the metabolism,
pharmacokinetics and mechanisms of the antiviral activity of ribavirin against HCV, all of which are central to the rational
identification of improved treatment protocols.
Received 30 September 2005; received after revision 20 November 2005; accepted 7 December 2005 |
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Keywords: | Mutagenesis treatment response viral dynamics mathematical model monotherapy combination therapy |
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