| 红菇多糖对小鼠肝脏衰老的抑制效果 |
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| 引用本文： | 魏杰,张潇,张国坤,万冬梅,林景峰,孙淑华.红菇多糖对小鼠肝脏衰老的抑制效果[J].北京工商大学学报(自然科学版),2017,35(3):50-54. |
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| 作者姓名： | 魏杰 张潇 张国坤 万冬梅 林景峰 孙淑华 |
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| 作者单位： | 辽宁大学 生命科学院, 辽宁 沈阳 110036,辽宁大学 生命科学院, 辽宁 沈阳 110036,辽宁大学 生命科学院, 辽宁 沈阳 110036,辽宁大学 生命科学院, 辽宁 沈阳 110036,辽宁仙人洞国家级自然保护区管理局, 辽宁 大连 116407,辽宁仙人洞国家级自然保护区管理局, 辽宁 大连 116407 |
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| 基金项目： | 辽宁仙人洞国家级自然保护区大型真菌资源调查项目； 辽宁省教育厅教学研究项目(LYB201611)； 辽宁省社会科学规划基金资助项目(L15BJY029)。 |
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| 摘 要： | 研究红菇多糖对衰老昆明小鼠肝功能衰退的抑制作用。使用D-半乳糖建立衰老模型,并在此期间给予75mg/L与150mg/L红菇多糖饮水。8周后断颈处死,检测肝指数、血清和肝组织的谷胱甘肽过氧化物酶、超氧化物歧化酶活性及丙二醛含量,同时对肝组织Ca2+-ATPase活性及形态学进行分析。结果表明,8周内给予红菇多糖150mg/L饮水时,小鼠肝指数、谷胱甘肽过氧化物酶、超氧化物歧化酶活性得到显著提高,丙二醛含量显著下降,小鼠肝功能衰退得到了显著抑制(p＜0.05),肝脏的衰老及损伤也得到了有效抵制。
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| 关 键 词： | 红菇多糖 肝脏 抗衰老 |
| 收稿时间： | 2016/9/21 0:00:00 |
Inhibitory Effect of Russula farinipes Romell Polysaccharide on Mice Liver Senescence |
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| WEI Jie,ZHANG Xiao,ZHANG Guokun,WAN Dongmei,LIU Jingfeng and SUN Shuhua.Inhibitory Effect of Russula farinipes Romell Polysaccharide on Mice Liver Senescence[J].Journal of Beijing Technology and Business University:Natural Science Edition,2017,35(3):50-54. |
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| Authors: | WEI Jie ZHANG Xiao ZHANG Guokun WAN Dongmei LIU Jingfeng and SUN Shuhua |
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| Institution: | School of Life Science, Liaoning University, Shenyang 110036, China,School of Life Science, Liaoning University, Shenyang 110036, China,School of Life Science, Liaoning University, Shenyang 110036, China,School of Life Science, Liaoning University, Shenyang 110036, China,Liaoning Xianrendong National Nature Reserve Administration Bureau, Dalian 116407, China and Liaoning Xianrendong National Nature Reserve Administration Bureau, Dalian 116407, China |
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| Abstract: | Effects of Russula polysaccharide on mice hepatic insufficiency were investigated in this study. The senile model mice were established by D-galactose and mice were treated by 75mg/L and 150mg/L Russula polysaccharide. After 8 weeks, liver index, serum and hepatic GSH-Px, SOD activity, MDA contents, Ca2+-ATPase activity and hematoxylin-eosin staining of mice were determined. The results showed that the treatment of 150mg/L Russula polysaccharide could increase liver index, GSH-Px and SOD activity, and decrease the MDA content, which could inhibit the aging of liver. |
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| Keywords: | Russula polysaccharide liver anti-aging |
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