Effect of chronic administration of morphine on primary immune response in mice |
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Authors: | M Güngör E Genç H Sa?duyu L Ero?lu H Koyuncuo?lu |
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Institution: | (1) Department of Pharmacology and Clinical Pharmacology, Istanbul Medical Faculty, Istanbul University, Capa, Istanbul, (Turkey) |
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Abstract: | Summary The effect of 3 different doses of chronically-administered morphine on the primary immune response was studied in mice by estimating spleen/body weight ratio and serum hemolysin production against sheep red blood cells (SRBC). It was observed that morphine exerted a dose-dependent inhibitory effect on the immune response which was antagonized by the concomitant administration of naloxone. The findings suggest that the inhibitory effect of morphine is specific. |
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