Acyl-kallikrein; a delivery system for the kinin-liberating enzyme |
| |
Authors: | F. Markwardt J. Stürzebecher H. Müller |
| |
Affiliation: | (1) Institute of Pharmacology and Toxicology, Medical Academy Erfurt, DDR-5010 Erfurt, (German Democratic Republic) |
| |
Abstract: | Summary Glandular kallikrein can be temporarily acylated at the active centre by 4-amidinophenyl benzoates. The time course of reactivation depends on the nature of the acyl group introduced. Benzoyl kallikrein was used as a delivery system for kallikrein in vivo. In rabbits, bolus injection of the acylated enzyme caused a long-lasting drop in blood pressure due to sustained kinin liberation. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |