Effect of actinomycin D or puromycin on microsomal testosterone hydroxylase activity enhanced by testosterone in female rat liver |
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| Authors: | N. Sato M. Ota K. Obara |
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| Affiliation: | (1) Department of Biochemistry, Iwate Medical University School of Medicine Morioka, 020 Iwate-Ken, Japan |
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| Abstract: | Summary The injection of testosterone propionate for 4 successive days into female rats resulted in an increase of the in vitro conversion of the hydroxylated testosterones from testosterone by the hepatic microsomal, fraction, but no change in the content of microsomal cytochrome P-450 occurred. Actinomycin D or puromycin, which was administered for 4 days with injections of testosterone propionate, prevented the enzyme induction. |
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