| 宽体金线蛭鲜品和干品提取物体外抗凝血活性研究 |
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| 引用本文： | 万明,唐仕欢,游云,刘义梅,陈科力. 宽体金线蛭鲜品和干品提取物体外抗凝血活性研究[J]. 中南民族大学学报(自然科学版), 2012, 31(1): 47-50 |
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| 作者姓名： | 万明 唐仕欢 游云 刘义梅 陈科力 |
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| 作者单位： | 1. 湖北中医药大学教育部中药资源和中药复方重点实验室,武汉,430065
2. 中国中医科学院中药研究所,北京,100700 |
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| 基金项目： | 中国中医科学院基金资助项目(ZZ20090402):水蛭抗凝血活性多肽的分离鉴定及其筛选研究;湖北省教育厅优秀中青年人才项目(Q20081603) |
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| 摘 要： | 目的：研究宽体金线蛭鲜品和干品提取物的体外抗凝血活性.方法：不同浓度的两种提取物分别作用于大鼠血浆后,检测其对血浆PT、APTT、FIB及粘度的影响.结果：宽体金线蛭的2种提取物对血浆PT、APTT、FIB均有不同程度的影响,并呈现明显量效关系,对血浆粘度的影响不明显.结论：2种宽体金线蛭的提取物具有明显的抗凝活性,体外初步实验表明：鲜品宽体金线蛭的抗凝血活性略强于干品.
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| 关 键 词： | 宽体金线蛭 体外抗凝血活性 量效关系 |
Study on Anticoagulant Activities of Extracts in Vitro from Dried and Fresh Materials of Whitmania pigra |
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| Wan Ming,Huang Luqi,You Yu,Liu Yimei,Chen Keli. Study on Anticoagulant Activities of Extracts in Vitro from Dried and Fresh Materials of Whitmania pigra[J]. Journal of South-Central Univ for, 2012, 31(1): 47-50 |
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| Authors: | Wan Ming Huang Luqi You Yu Liu Yimei Chen Keli |
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| Abstract: | Objective: In vitro study on the anticoagulant activities of extracts from dried and fresh materials of Whitmania pigra.Methods: Two extracts with different concentrations was observed to evaluate their influence on PT、APTT、FIB and the viscosity of plasma.Result: The two extracts of Whitmania pigra showed different levels of influence on PT、APTT and FIB in a dose-dependent effect,but had no obvious action on the viscosity of plasma.Conclusion: The two extracts of Whitmania pigra possess obvious anticoagulant activities,and the extract from presented higher effect then that from dried one in the anticoagulant activity. |
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| Keywords: | Whitmania pigra anticoagulant activities in vitro dose-effect relationship |
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