| 2,4-二氯氟苯的合成 |
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| 引用本文： | 张继昌,石蔚云,王国喜. 2,4-二氯氟苯的合成[J]. 应用科技, 2004, 31(4): 67-68 |
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| 作者姓名： | 张继昌 石蔚云 王国喜 |
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| 作者单位： | 安阳大学,化工系,河南,安阳,455000 |
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| 摘 要： | 2，4—二氯氟苯是合成喹诺酮类抗生素的重要中间体，随着环丙氟哌酸的广泛应用，国内外2，4—二氯氟苯需求急剧增加。在此概述了由2，4—二氯苯胺经过重氮化、置换制得2，4—二氯氟苯的生产新工艺，产品纯度达到99．2％，收率50．2％。新工艺具有安全可靠，原材料易得，成本较低，产品纯度高等优点，比较适宜于工业化生产。
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| 关 键 词： | 2，4—二氯氟苯 合成工艺 喹诺酮类抗生素 中间体 |
| 文章编号： | 1009-671X(2004)04-0067-02 |
| 修稿时间： | 2003-02-15 |
Synthesis of 2,4-dichloro fluorobenzene |
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| ZHANG Ji-chang,SHI Wei-yun,WANG Guo-xi. Synthesis of 2,4-dichloro fluorobenzene[J]. Applied Science and Technology, 2004, 31(4): 67-68 |
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| Authors: | ZHANG Ji-chang SHI Wei-yun WANG Guo-xi |
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| Abstract: | 2,4-Dichlorofluorobenzene is an organic intermediate for synthesizing ciprofloxacin,a broadspectrum antibiotics.With increasing consumption of ciprofloxacin,the demand for 2,4-Dichlorofluorobenzene is increasing at home and abroad.2,4-Dichlorofluorobenzene is prepared by diazotizating of 2,4-dichloro aniline and substituting of 2,4-dichloro diazo benzene with fluorinion.The purity is 99.2% and the yield is (50.2%.)This new process is simple and suitable for industrial production. |
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| Keywords: | 2 4-dichloro aniline 2 4-dichloro fluorobenzene quinoxalone antibiotics intermi-diate synthesis. |
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