|
|||||
|
|
| 雄性大鼠海马多巴胺受体的增龄性改变 | |
| 引用本文： | 宋士一,马宏,王金玲.雄性大鼠海马多巴胺受体的增龄性改变[J].沈阳师范大学学报(自然科学版),2001,19(3):52-54. |
| 作者姓名： | 宋士一 马宏 王金玲 |
| 作者单位： | 1. 沈阳师范学院化学与生命科学学院, 2. 沈阳医学院生物化学系， 3. 沈阳出入境检疫局, |
| 摘 要： | 采用放射配基结合分析法初步观察了大鼠海马多巴胺(Dopamine,简称DA)受体的增龄性变化及腹腔注射使DA受体不可逆失活的EEDQ(N-乙氧羰基-2乙氧基-2双氧喹啉)后，DA受体的恢复情况.结果表明老年大鼠海马DA受体结合力较青年大鼠差异不明显，注射EEDQ后两者DA受体亲和力均明显降低，但恢复时青年大鼠恢复的速度快于老年鼠者.表明老年大鼠海马DA受体比青年大鼠更容易受到伤害，恢复也更困难，这些变化可能与老年期的一些表现及老年病的学习记忆紊乱有一定关系. |
| 关 键 词： | 衰老 海马 多巴胺受体 |
| 文章编号： | 1008-374X(2001)03-0052-03 |
| 修稿时间： | 2000年11月3日 |
Age-added change of dopamine receptor in male rats |
|
| SONG Shi_yi,MA Hong,WANG Jin_ling.Age-added change of dopamine receptor in male rats[J].Journal of Shenyang Normal University: Nat Sci Ed,2001,19(3):52-54. | |
| Authors: | SONG Shi_yi MA Hong WANG Jin_ling |
| Abstract: | Age-added change of dopamine (DA) receptor in the hippocampi gyrus and recovery of DA receptor after EEDQ (i.p.)was observed by means of radiogland binding assay. The results demonstrated that no significant difference was revealed between aging group and young group. Both of groups DA receptor binding droped evidently after EEDQ (i.p.)but recovery of young group was quicker than one of aging group. The results suggested that DA receptor in aging hippocampi gyrus was damnified easily and recovered arduously. The change described above may be related with the characteristic of aged and senile studying and remembrance disorder. |
| Keywords: | aging hippocampi gyrus dopamine receptor |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |