Purine nucleotide cycle as a possible anaplerotic process in rat skeletal muscle

Summary The intermediates of the purine nucleotide cycle (PNC) stimulated pyruvate oxidation by isolated skeletal muscle mitochondria in a system containing mitochondria and cytosol from rat skeletal muscle. Thus, in skeletal muscle the PNC might be involved in the anaplerotic supply of tricarboxylic acid cycle intermediates.Acknowledgment. This work was supported by a grant from the Polish Academy of Science within the project MR II.1.2.4.