Beta-adrenergic receptors in rat myocardium: Direct detection by a new fluorescent beta-blocker |
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| Authors: | E. Melamed M. Lahav Daphne Atlas |
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| Affiliation: | (1) Department of Neurology, Laboratory for Cerebrovascular Research and Opthalmic Pathology Laboratory, Hadassah Hospital and Hebrew University, Hadassah Medical School, P. O. Box 499, Jerusalem;(2) Department of Biological Chemistry, Hebrew University, 20 Mamilla Road, Jerusalem, Israel |
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| Abstract: | Summary A new fluorescent  -blocker, 9-amino-acridin propranolol (9-AAP), was administered i.v. to rats. Multiple fluorescent 9-AAP binding sites were observed on cardiac muscle cells in frozen sections. Intensity and density of cardiac 9-AAP fluorescence were markedly reduced following pretreatment with (±)- and (–)-propranolol but not with (+)-propranolol. Our findings suggest that 9-AAP may label -adrenergic receptor sites in rat myocardium.D. A. is supported by a fellowship from the Lady Davis Fellowship Trust and by a Research Grant from the Bat-Sheva de Rothschild Fund for The Advancement of Science and Technology. The technical assistance ofA. Itzhak is gratefully acknowledged. |
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