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两种短效胰岛素对糖尿病酮症酸中毒的疗效对比
引用本文:习涛,程泽君,邢新军,顾伟.两种短效胰岛素对糖尿病酮症酸中毒的疗效对比[J].科技导报(北京),2022,40(12):118-122.
作者姓名:习涛  程泽君  邢新军  顾伟
作者单位:北京市垂杨柳医院急诊科, 北京 100021
基金项目:北京市朝阳区科技计划项目(CYSF2049)
摘    要: 以北京市垂杨柳医院2017年5月至2020年5月收治的50例糖尿病DKA患者为研究对象,分为赖脯组和门冬组(n=25),赖脯组使用重组赖脯胰岛素,门冬组使用门冬胰岛素。结果显示,两组的血糖达标时间、不良反应发生情况无统计学差异(P>0.05);赖脯组患者空腹血糖、餐后2 h血糖水平低于门冬组,且尿酮体转阴时间、pH值恢复时间短于门冬组。说明赖脯胰岛素治疗DKA具有一定的优势,其控制血糖、纠正DKA的速度更快,效果更好。

关 键 词:酮症酸中毒  赖脯胰岛素  门冬胰岛素  疗效评价  安全性评价  
收稿时间:2022-02-07

Clinical efficacy of different insulin regimens in the treatment of diabetic ketoacidosis
XI Tao,CHENG Zejun,XING Xinjun,GU Wei.Clinical efficacy of different insulin regimens in the treatment of diabetic ketoacidosis[J].Science & Technology Review,2022,40(12):118-122.
Authors:XI Tao  CHENG Zejun  XING Xinjun  GU Wei
Institution:Emergency Department of Beijing Chuiyangliu Hospital, Beijing 100021, China
Abstract:In this study, 50 DKA patients admitted in our hospital from May 2017 to May 2020 are included as the subjectsin this study, and they are divided into the Insulin Lispro group and the Insulin Aspart group. It is shown that there is no significant difference in the recovering time of the blood glucose, and the complication rates between the two groups (P>0.05); in the Lispro group, the fasting blood glucose and the postprandial 2 h blood glucose levels are lower than those in the Aspart group, and the recovery times of the negative urinary ketone and the bloody pH value are shorter than those in the Aspart group. It is suggested that the insulin Lispro has certain advantages in the treatment of the DKA, with higher speeds of controlling the blood glucose and correcting the DKA.
Keywords:diabetic ketoacidosis  insulin Lispro  insulin Aspart  efficacy evaluation  safety evaluation  
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