| 以胶体粒子为模板制备含磁药物胶囊 |
| |
| 引用本文： | 杨晓玲,韩霄,答鸿,朱以华,李春忠.以胶体粒子为模板制备含磁药物胶囊[J].华东理工大学学报(自然科学版),2006,32(5):568-571,606. |
| |
| 作者姓名： | 杨晓玲 韩霄 答鸿 朱以华 李春忠 |
| |
| 作者单位： | 1. 华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海,200237
2. 华东理工大学石油化工学院,上海,201512 |
| |
| 基金项目： | 中国科学院资助项目
,
高比容电子铝箔的研究开发与应用项目
,
上海市重点基础研究项目
,
上海市纳米科技专项基金 |
| |
| 摘 要： | 以低度交联的单分散三聚氰胺甲醛(M F)微球作为胶体模板,采用层层静电自组装技术,交替组装带正电的聚二烯丙基二甲基氯化铵(PDDA)和带负电的聚4-苯乙烯磺酸钠(PSS),得到具有核壳结构的复合微球,然后利用盐酸溶液将模板M F微球溶解,制得均匀的空腔胶囊。在N aC l浓度为0.7 m o l/L,pH<3时,将抗癌药物盐酸多柔米星(DOX)和磁流体同时封装到聚电解质胶囊中,可得到含磁药物胶囊,磁性粒子分散在胶囊的壳层和空腔内。该含磁药物胶囊具有良好的磁响应性和药物缓释性。
|
| 关 键 词： | 层层自组装 核壳式微球 含磁药物胶囊 载药 |
| 文章编号： | 1006-3080（2006）05-0568-04 |
| 收稿时间： | 2005-04-23 |
| 修稿时间： | 2005年4月23日 |
Fabrication of Magnetic Polyelectrolyte Dexorubicin Hydrochloride Capsules Templated on Colloidal Particles |
| |
| YANG Xiao-ling,HAN Xiao,DA Hong,ZHU Yi-hua,LI Chun-zhong.Fabrication of Magnetic Polyelectrolyte Dexorubicin Hydrochloride Capsules Templated on Colloidal Particles[J].Journal of East China University of Science and Technology,2006,32(5):568-571,606. |
| |
| Authors: | YANG Xiao-ling HAN Xiao DA Hong ZHU Yi-hua LI Chun-zhong |
| |
| Abstract: | Uniform hollow capsules were produced by layer-by-layer electrostatic self-assembly technique.The core-shell microspheres were constructed by alternately depositing negative and positive polyelectrolyte onto the weakly-crosslinked melamine formaldehyde(MF) microspheres which were used as the colloidal templates, then the templates were dissolved by 0.1 mol/L hydrochloric acid and hollow capsules came into being.The anti-cancer drug dexorubicin hydrochloride(DOX) and magnetic fluid were encapsulate in the hollow capsules simultaneously in the 0.7 mol/L NaCl solution at pH<3.Magnetic particles are dispersed in the wall and interior of capsules.The capsules loaded drug and magnetic particles have both good magnetic responsibility and controlled release property. |
| |
| Keywords: | layer-by-layer self-assembly core-shell microspheres magnetic polyelectrolyte DOX capsules drug loading |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
