The effect of camphor on mitochondrial respiration |
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| Authors: | D. F. Guilland-Cumming G. J. Smith |
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| Affiliation: | (1) Physics and Engineering Laboratory, Department of Scientific and Industrial Research, Private Bag, Lower Hutt, (New Zealand);(2) Present address: Department of Human Metabolism and Clinical Biochemistry, Medical School, University of Sheffield, Beech Hill Road, S10 2RX Sheffield, (England) |
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| Abstract: | Summary Camphor at <8  moles/mg protein reduced the rate of oxygen consumption by rat liver mitochondria. The effect occurs only with NAD+-linked substrates. Succinate linked respiration was inhibited but this appears to be caused by some conversion of succinate to malate. At higher levels, camphor increases oxygen consumption with succinate substrate, by uncoupling at site II.Acknowledgment. D.F.G.-C. is grateful to the New Zealand Cancer Society (Wellington Branch), for financial support. We thank Mrs E. Dye for technical assistance and Dr W. Jordan for valuable discussions. |
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