基于矩阵填充的肿瘤基因表达谱数据缺失点估计

为解决肿瘤基因表达谱数据后续研究需要完整数据矩阵的问题,针对包含缺失点的数据集。提出基于矩阵填充(matrix completion)与模糊C均值(fuzzy c-means algorithm,FCM)相结合的缺失点估计方法(FCM_MC)。该方法充分利用肿瘤基因表达谱数据的冗余信息,通过模糊C均值聚类得到具有良好的低秩特性的基因语义片段,再利用矩阵填充方法分别对每个语义片段进行缺失点的重建。在不同数据集上进行实验,与传统缺失点估计算法比较。实验表明FCM_MC算法在缺失数据估计准确度和类结构保持度上效果得到有效提升,同时运行效率较高。

Tumor gene expression missing value estimation based on matrix completion

To solve the problem that the research of tumor gene expression data needs a complete data matrix, a missing value estimation method (FCM_MC) based on matrix completion (MC) and fuzzy c-means algorithm (FCM) is proposed for matrices contain missing values. The method makes full use of the redundancy information of tumor gene expression data, the low rank genetic semantics matrices are obtained by fuzzy c-mean clustering method. Then we use matrix completion theory to estimate the missing values of every semantics matrices. After the estimation of different data sets, we compared our proposal with tradition missing value estimation algorithm. Experimental results show the improvement of our method on missing value estimation accuracy and structure of class preserving accuracy with suitable efficiency.