The mutagenic mode of action of benzimidazole

Summary By using a bacterial mutant strain with a known restricted reversion pattern, it has been shown that benzimidazole induces an unidirectional base change also in vivo. The in vitro demonstrated strict GA transition has thus been confirmed.Acknowledgments. I thank Th. Thurnher for his technical assistance. My thanks go furthermore to Dr Charles Yanofsky (Stanford University, California, USA), who generously supplied hisEscherichia coli strains.