Calcium and the contractile response to prostaglandin in the smooth muscle of guinea-pig stomach |
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Authors: | M Ishizawa E Miyazaki |
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Institution: | (1) Department of Physiology, Sapporo Medical College, W. 17, S. 1 Sapporo, (Japan) |
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Abstract: | Summary In the longitudinal smooth muscle of guinea-pig stomach, verapamil (10–5 M) which showed marked suppression of high K-induced contractures, did not suppress the contractile response to PGE1 (1.5×10–9 to 10–6 M) markedly. These results suggest that the contractile mechanism of PGE1 in guinea-pig stomach may mainly depend on a release of bound Ca in the cell and partly depend on a Ca influx from the extracellular origin. |
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