| 正交设计优化棉酚结晶法拆分衍生化工艺 |
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| 引用本文： | 代友彪,唐辉,张欢,关丽,杨四涛.正交设计优化棉酚结晶法拆分衍生化工艺[J].石河子大学学报,2009,27(6):747-749. |
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| 作者姓名： | 代友彪 唐辉 张欢 关丽 杨四涛 |
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| 作者单位： | 石河子大学药学院／新疆特种植物药资源教育部重点实验室,石河子832002 |
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| 基金项目： | 教育部科学技术研究重点项目，新疆生产建设兵团博士基金 |
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| 摘 要： | 为优化棉酚结晶法拆分关键过程——衍生化反应的工艺条件。采用正交设计法，重点考察反应温度、衍生化料液体积、反应时间3个因素对结晶产物收率的影响。衍生化料液体积对反应结晶产物收率的影响最为显著，其次是反应温度和时间。因此可知，优化的棉酚结晶法拆分衍生化工艺稳定、合理可行。
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| 关 键 词： | 棉酚 衍生化反应 正交设计 |
Study on Technology of Resolution of the Optical Active Derivatives of Gossypol by Crystallization Method by Orthogonal Designing Method |
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| DAI Youbiao,TANG Hui,ZHANG Huan,GUAN Li,YANG Sitao.Study on Technology of Resolution of the Optical Active Derivatives of Gossypol by Crystallization Method by Orthogonal Designing Method[J].Journal of Shihezi University(Natural Science),2009,27(6):747-749. |
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| Authors: | DAI Youbiao TANG Hui ZHANG Huan GUAN Li YANG Sitao |
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| Institution: | ( College of pharmacy, Shihezi University/Key Laboratory of Xinjiang Phytomedicinal Resources,Shihezi 832002, China) |
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| Abstract: | To study and optimize on the Key processes of the resolution of the optical active derivatives of gsssypol by crystallization method Conditions of Derivatized. Using the orthogonal design to study the influence of temperature, reaction time and solvent on the yield of recrystallization is investigated. The effects of ratio of reaction solvent on the yield of the product was most remarkable, and next came reaction temperature and time. The optimal process is stable and feasible. |
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| Keywords: | gossypol derivative reaction orthogonal design |
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