细胞周期与细胞凋亡共同的调控分子--Survivin蛋白(综述)

细胞周期与细胞凋亡是有着紧密联系的生命活动。尽管凋亡调控蛋白常常牵涉到细胞周期的调控，但是细胞周期与细胞凋亡共同的的调控分子却很少见。一个新的抗凋亡蛋白——Survivin蛋白，最近被发现同时具有调控细胞凋亡和细胞周期的双重功能，这为细胞周期与细胞凋亡之间存在紧密联系提供了有力的证据。另一方面，它的表达和分布特点对细胞增殖非常有利，提示Survivin蛋白可能是快速增殖细胞(如癌细胞)重要的测控分子。

A common regulator of cell cycle and apoptosis--Survivin (A review)

Cell cycle and apoptosis are thought to be intimately linked processes in life activities. Although regulators of apoptosis are involved in regulation of cell cycle, the common regulators of cell cycle and apoptosis are still few. A new inhibitor of apoptosis, survivin, has been found as a dual functional molecule controlling of apoptosis and mitotic spindle checkpoint, which also gives a powerful proof for that cell cycle and apoptosis are intimately linked processes. On the other hand, it's expression and distribution are very beneficial to proliferation,so that it may be an important regulator in cancer cells.