Chromosome fragility and susceptibility of Bloom's syndrome fibroblasts to SV40 transformation |
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| Authors: | M S Lin O S Alfi |
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| Institution: | (1) Division of Medical Genetics, Children's Hospital of Los Angeles, Los Angeles, USA;(2) Department of Pediatrics, University of Southern California, 90027 Los Angeles, California, USA;(3) Present address: Department of Medical Genetics, Moorer Clinical Sciences Bldg. Rm. 1106, USA Medical Center, Fillingim St., 2451 Mobile, Alabama 36617, USA |
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| Abstract: | Summary A comparison of the frequencies of chromosomal aberrations and the rates of SV40 transformation was made using fibroblasts obtained from 2 patients with Bloom's syndrome (BS) and from a normal individual. BS cells were found to be more susceptible to chromosome damage, in confirmation of earlier reports, but surprisingly, BS cells were distinctly less prone to transformation.Supported in part by the Michael J. Connell Foundation Medical Genetics Fund, and Health, Education and Welfare, MCH project 422. |
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